pentobarbital will raise the degree or impact of ivosidenib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of ivosidenib with potent CYP3A4 inducers diminished ivosidenib plasma concentrations.pentobarbital will decrease the extent or impact of finasteride by influencing hepatic/intestinal en